CNGB1 and retinal degeneration: Therefore, an abnormal CNG channel resulting from a mutation in CNGB1 affecting at least the channel transcript would be expected to result in a compromised retinal rod phototransduction and lack of conversion of odor stimuli into electric signals by the OSNs, leading to both retinal degeneration and olfactory dysfunction [6,13,14,15]—an association that was established in mice by Hüttl et al. and Michalakis et al. [16,17].