SODD can bind to SKIP to inhibit the dephosphorylation of PI(3,4,5)P3 to PI(3,4)P2 and enhance AKT phosphorylation to promote the migration of COS-7 cells [23].Furthermore, overexpression of SODD in colorectal cancer cells increases AKT phosphorylation and enhances glucose uptake [24]. This evidence concerns the gene BAG4 and colorectal cancer.