As the knockout mice in the experiment performed by Chen et al. (2017) [31] were resistant to obesity due to increased energy expenditure, it is possible that rs1554116, which is considered a risk allele for obesity, can cause the increased expression of KCNK13 and defective thermogenesis, but further research and functional experiments are required to support this assumption. Here, KCNK13 is linked to obesity due to melanocortin 4 receptor deficiency.