As the knockout mice in the experiment performed by Chen et al. (2017) [31] were resistant to obesity due to increased energy expenditure, it is possible that rs1554116, which is considered a risk allele for obesity, can cause the increased expression of KCNK13 and defective thermogenesis, but further research and functional experiments are required to support this assumption. The gene discussed is KCNK13; the disease is obesity disorder.