HSPs are induced or changed in response to virus infection, and are involved with the viral replicase complex (VRC) or other viral macromolecular protein complexes, helping the virus to complete different steps of viral multiplication, replication, translocation, assembly, disassembly, etc. Nevertheless, HSP inhibitors can regulate HSPs by various mechanisms, thus displaying different bioactivities, including anticancer and antiviral activities. Here, HSP90B2P is linked to viral infectious disease.