Through meta-analysis of whole-exomes from 24,248 cases and 97,322 controls, the SCHEMA consortia reported that ultra-rare coding variants in 10 genes (TRIO, CUL1, XPO7, SP4, SETD1A, CACNA1G, GRIA3, HERC1, RB1CC1, and GRIN2A) confer substantial risk for schizophrenia (odds ratios 3–50, p < 2.14 × 10−6) [14]. This evidence concerns the gene GRIN2A and schizophrenia.