Indeed, an association between LBR and the shelterin TRF2 has been reported, but not with TRF1 [172], and depletion of LBR leads to an upregulation of TRF1 together with an induction of chromosomal instability (i.e., chromosomal losses and translocations) in colorectal cancer cells. Here, TERF1 is linked to colorectal cancer.