GPT and obesity due to melanocortin 4 receptor deficiency: Although some lactobacilli are related to weight gain, most lactobacilli have anti-obesity effects [64]; Lactobacillus reuteri is a flora that can promote weight gain [65], and Lactobacillus acidophilus can reduce the level of triglycerides and the activities of aspartate aminotransferase and alanine aminotransferase, and significantly inhibit the development of obesity and lipid deposition in the liver of ICR mice fed with HFD [66].