IL6 and obesity due to melanocortin 4 receptor deficiency: On the other hand, although oxidative stress promotes inflammation under obesity status [48], we further analyzed the anti-inflammatory properties of Morus alba L. Specifically, M. alba L. leaf extracts showed beneficial effects against the inflammatory status present in HFD-mice, evidenced by the ability of the extract to reduce the expression levels of COX-2 in epididymal fat and IL-6 in the liver.