A recent meta-analysis has indicated that reduced levels of the pre and postsynaptic proteins, such as synaptosome-associated protein of 25 kDa (SNAP-25), PSD-95, synapsin, and rab3A in the hippocampus and a reduction of synaptophysin in the hippocampus and frontal cortical regions are consistent with models involving a synaptic loss in schizophrenia [76,79,80,81,82,83]. This evidence concerns the gene SNAP25 and schizophrenia.