This work highlights the great influence of CYP19A1 codon 39 Trp/Arg (T/C) polymorphism (rs2236722) and GSTM1 and GSTT1 polymorphisms in female fertility and brings to discussion the value of assessing low penetrance polymorphisms to prevent infertility in the general population of women. This evidence concerns the gene CYP19A1 and Infertility.