We interestingly found that the TC/CC variant seems to be associated with the development of endometriosis and speculated about the possible role of this polymorphism in augmenting CYP19A1 enzymatic activity, and thus enhancing estrogen production; the results obtained for PCOS and POF, diseases that are associated with lower estrogen levels, led us to doubt about our speculation of the role of the polymorphism on the protein activity. This evidence concerns the gene CYP19A1 and polycystic ovary syndrome.