The gelatinolytic activity of active MMP-2 isoform (65 Kda) in placenta was higher in the HTN-Preg group compared to Norm-Preg, Norm-Preg + Prava, and HTN-Preg + Prava groups (Figure 7D and Supplementary Table S1), while gelatinase activity of both inactive MMP-2 isoforms (75 Kda and 72 Kda) showed no differences among the four groups (Figure 7B and Figure 7C, respectively, and Supplementary Table S1). This evidence concerns the gene MMP2 and hypertensive disorder.