TP53 and cancer: A study in 2005 showed that the hyperthermic augmentation of tumor growth suppression by irradiation is dependent on the p53 gene state, using two types of cancer cell lines with different p53 gene statuses (wtp53, mp53), treated with a combination of X-ray irradiation (2 Gy) and HT (42 °C, 20 min) [59].