IMMT and colorectal carcinoma: As shown in Figure 4C, normal/non-ischemic Mitofilin+/− mitochondria respond similarly to WT mitochondria in their ability to retain Ca2+ (300 ± 12 nmol/mg of mito protein in WT-normal versus 293 ± 7 nmol/mg of mito protein in Mitofilin+/− normal), with a higher CRC reflecting greater resistance to mPTP opening.