SNCA and early-onset autosomal dominant Alzheimer disease: Furthermore, 4-hydroxy-2,3-trans-nonenal (4-HNE), the end-product of ferroptosis, promotes the inflammatory response by producing amyloid-beta (Aβ) fibrils and neurofibrillary tangles in Alzheimer’s disease, and alpha-synuclein aggregation in Parkinson’s disease.