CD44 and cancer: Epican (extracellular matrix receptor III, CD44), as a multifunctional cell surface adhesion receptor, is a regulator of the progression and metastasis of cancer cells [258] in the context of glycan-mediated iron endocytosis during EMT, in which iron operates as a metal catalyst to demethylate repressive histone marks that govern the expression of mesenchymal genes [259].