On the other hand, in OS conditions (Figure 1) ROS has a role in the regulation of NF-κB signaling as well as Nrf2 signaling, resulting in abnormal bleeding and uncontrolled apoptosis [14,21,26] in pathological processes and diseases such as endometriosis, polycystic ovary syndrome (PCOS), and tubal and idiopathic infertility [27,28,29]. This evidence concerns the gene NFKB1 and polycystic ovary syndrome.