Specifically, hepatic macrophages, which consist of resident Kupffer cells and recruited bone marrow-derived macrophages, are the major cells that produce inflammatory mediators, such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β, causing systemic insulin resistance followed by NAFLD and, ultimately, NASH [24]. This evidence concerns the gene IL1B and metabolic dysfunction-associated steatohepatitis.