In previous studies, Voronkova et al. [165,166] evaluated the ability of SkQ1 to restore hyperglycemia-induced oxidative stress in diabetic rat models via attenuating mtROS, and decreasing the burden on the antioxidant machinery such as catalase, superoxide dismutase, glutathione, and NAPDH-generating enzymes [165,166]. The gene discussed is CAT; the disease is Hyperglycemia.