The impact of MALAT-1 on neurological function was validated in a rat model of diabetes and after gain-and-loss of function studies in HG-cultured brain microvascular endothelial cells (BMEC), demonstrating that inhibiting lncRNA MALAT1 by siRNA lessens apoptosis of microvascular endothelial cells cultured in high glucose via activating the miR-7641/TPR axis [123]. This evidence concerns the gene MALAT1 and diabetes mellitus.