On the other hand, antioxidant enzymes such as nuclear factor erythroid-2-related factor-2 (Nrf2) and heme oxygenase-1 (HO-1) maintain redox equilibrium by regulating oxidative stress [17], and, thus, the activation of antioxidant defense enzymes provides an alternative strategy for treating AD. The gene discussed is NFE2L2; the disease is Alzheimer disease.