TGFB1 and cancer: Various biological activities have been reported for SHK, including anti-inflammation, anti-cancer, cardiovascular protection, and anti-microbiome effects, mainly by regulating the NF-κB, PI3K/Akt/MAPKs, Akt/mTOR, TGF-β, GSK3β, TLR4/Akt signaling pathways, i.e., the main pathways of cancer cell survival [14].