Ando et al. recently reported in head and neck squamous cell carcinoma that Egfr could activate Yap1 by phosphorylating Mob1, which further dephosphorylates Lats1/2, thereby inactivating Lats1/2 that leads to the activation of Yap1 [22]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.