In fact, Gao et al. linked a deficiency of solute carrier family 27 member 5 (SLC27A5/FATP5), which leads to an increase in PUFA, to accumulation of HNE adducts and activation of the NRF2/TrxR1 axis to treatment resistance in hepatocellular carcinoma. Here, SLC27A5 is linked to hepatocellular carcinoma.