In the same work, the authors described 4-HNE–His to be the major modification of proteins exposed to 4-HNE in vitro, whereas 4-HNE–His adducts were identified as ligands for LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1), which is an endothelial scavenger receptor for the uptake of oxidized LDL important in the pathogenesis of atherosclerosis [92]. Here, OLR1 is linked to atherosclerosis.