Apart from mediating vascular endothelial dysfunction, NOX2 was reported to be involved in mediating retinal ganglion cell death in various ocular disease models, such as traumatic optic neuropathy, glaucoma, I/R events and M1 muscarinic acetylcholine receptor deficiency [28,82,84,85]. Here, CYBB is linked to hyperinsulinemic hypoglycemia, familial, 4.