Gu et al. investigated the impact of chemerin overexpression on endothelial function, arterial stiffness, and early atherosclerosis in patients with hypertension and presented that a high chemerin serum level was an independent predictor of impaired endothelial function and increased arterial stiffness, even after adjustment for metabolic variables, inflammatory markers, and adipokines [112]. This evidence concerns the gene RARRES2 and hypertensive disorder.