Taking into consideration that both chemerin and its receptors are expressed in human placental tissue, in addition to the fact that there is evidence for enhanced chemerin secretion under hypoxia, we suggest that chemerin might be one of the molecules connecting the two stages of PE, leading in consequence to the onset of maternal symptoms, including hypertension, proteinuria, kidney and liver failure, and cerebrovascular events [7,108]. Here, RARRES2 is linked to liver failure.