Mice treated with IL-1β shRNA lentivirus or NS shRNA (Ctrl) lentivirus by DG regions inj + LPS (1 mg/kg, i.p.) or plac→ behav tests (memory deficits with NORT; anxiety-like behaviors with EZM; DLB with SPTand FST). Furthermore, the levels of MDA, SOD, Nrf2, HO-1, TNFα, VGF and BDNF were assayed. The gene discussed is SOD1; the disease is Anxiety.