CMS promoted DLB, TLR4/NFκB but suppressed Nrf2/HO-1; ADSC treatment had the opposite effect, ↑SPT and ↓ immobility on TST and FST. ADSC and BV2 microglia cell cocultures showed that the ↑ of TLR4 and NFκB induced by LPS was ↓ by treatment with Nrf2-overexpressing vector ADSCs, while the ↓ of Nrf2 decreased the inhibitory effect of ADSCs on LPS-induced TLR4 and NFκB expression. The ↑ of Nrf2 in ADSCs ↓ BV2 LPS-induced inflammatory factor secretion (MCP-1, TNF-α, IL-1β, and IL-6). Here, TLR4 is linked to Lewy body dementia.