EOP ↓ CORT-induced DLB in mice (by improving behav tests), ↓ CRH, ACTH and cortisol in the brain tissues, ↑the phosphorylation of PI3K and Akt in Hippoc neurons and PC12 cells, ↑ Nrf2 and ↓ the CORT-induced OS. It also ↓ CORT-induced Hippoc neuron injury and apoptosis and ↑ the proliferation ability and cell viability of PC12 cells. This evidence concerns the gene NFE2L2 and Lewy body dementia.