CORST → DLB in mice in behav tests, ↑ serum CORT/CRH/ACTH, ↑ NF-κB in the Hippoc and frontal cortex, and ↓ Nrf2. CORST ↑ IL-1β, TNF-α, iNOS NO and MDA while ↓ GSH and GST in Hippoc and frontal cortex. Catalpol administration suppressed the abnormalities of the above indicators. Here, POMC is linked to Lewy body dementia.