Agmatine ↓ CORST-induced DLB, ↑BDNF, synaptotagmin I, Ser and Glut levels; ↓the CORST-induced changes in the morphology of astrocytes and microglia in CA1 subregion of Hippoc; ↑ Nora, Ser, and Dopa levels, CREB phosphorylation, mature BDNF and synaptotagmin I immunocontents, in the Hippoc of Ctrl group. Agmatine’s ability to produce an AD-like effect was abolished in Nrf2(−/−) mice. The gene discussed is NFE2L2; the disease is Alzheimer disease.