↓ Keap1 and Nrf2 in the PFC, CA3 and DG of Hippoc in mice with DLB compared to Ctrl; ↑ serum levels of pro-inflammatory cytokines in Nrf2 KO mice compared to WT mice; ↓ BDNF and TrkB in PFC, CA3 and DG play a role in DLB of Nrf2 KO mice. TrkB agonist, 7,8-DHF, but not antagonist ANA-12, produced AD effects in Nrf2 KO mice. Pretreatment with Nrf2 activator sulforaphane (SFN) prevented the DLB induced after repeated SDS. This evidence concerns the gene KEAP1 and Alzheimer disease.