Keap1-Nrf2 system plays a key role in depression and dietary intake of SFN-rich food during juvenile stages and adolescence can confer stress resilience in adulthood (dietary intake of 0.1% glucoraphanin (a precursor of SFN) containing food during juvenile and adolescent stages also prevented the depression-like phenotype evoked in adulthood, after repeated social defeat stress). This evidence concerns the gene NFE2L2 and depressive disorder.