Rb1 treatment can rescue DLB-like social avoidance and behav despair of CSDS-induced mice. Rb1 attenuates pro-inflammatory cytokine production and inhibits the activation of NLRP3 inflammasome. Furthermore, Rb1 normalised OS following Nrf2/HO-1 and SIRT1 activation. Findings show that Rb1 attenuates NI. Here, HMOX1 is linked to Lewy body dementia.