13 mice per group: Ctrl, exposed to CUMS + plac, CUMS + PD 100 mg/kg/day delivered by oral gavage, CUMS + PD 200 mg/kg/day oral gavage. → SPT, FST, TST, SIT for depression and MBI, E + M for anxiety → killing → Hippoc neuronal culture and staining, IF for Iba-1 and GFAP in Hippoc CA1, CA3, and DG, rt-qPCR for Iba-1, Gfap, Gapdh, Hmox1, Nqo1, and Nrf2 forward and reverse primers, WB for synaptophysin and PSD-95, ELISA for DA, 5-HT, IL-1β, IL-6, and TNF-α. This evidence concerns the gene HMOX1 and depressive disorder.