(R)-KT can produce rapid and long-lasting AD-like actions in Nrf2 KO mice via TrkB signalling: (R)-KT significantly attenuated TST and FST ↑ immobility in Nrf2 KO mice; on the SPT, (R)-KT significantly ameliorated ↓ SPT preference. ↓ expression of GluA1 and PSD-95 in the mPFC of Nrf2 KO mice was significantly improved after a single (R)-KT injection and pretreatment with the TrkB antagonist ANA-12 (0.5 mg/kg) blocked the rapid and long-lasting AD-like effects of (R)-KT. ANA-12 significantly antagonised the beneficial effects of (R)-KT on ↓ expression of synaptic proteins in the mPFC. The gene discussed is NFE2L2; the disease is Alzheimer disease.