MT ameliorated LPS-induced behav abnormalities in a mouse model of acute systemic inflammation and depression and decreased NLRP3 inflammasome activation in mice hippocampi (qPCR, WB and IF staining). Beneficial actions of MT are partly and significantly dependent on Nrf2 and SIRT1 activation in LPS and ATP-challenged murine microglia. The gene discussed is SIRT1; the disease is depressive disorder.