Depression was induced with 3 h daily separation from mothers while weaning; mice with maternal separation-induced depression and CV comorbidities treated with fluoxetine or SAHA + fluoxetine ip →behav tests (OFT [horizontal and vertical locomotion], E + M (Y-maze), TST, FST, SPlT [grooming]) + gene analysis with RT- qPCR; content and gene expression of PPAR-α, NOX-2, -4, PGC-1α, and Nrf2. Here, NFE2L2 is linked to major depressive disorder.