SAHA reversed DLB and restored mitochondrial function in the heart via an effect on NOX-4 and mitochondrial biogenesis gene (PGC-1α and Nrf-2) expression levels. The authors speculated that when fluoxetine lacks effectiveness on cardiac mitochondrial biogenesis and cardiac NOX-4 gene expression, patients with depression may develop a recurrence of their depression. The gene discussed is NFE2L2; the disease is major depressive disorder.