Hippoc cytoplasmic and nuclear Nrf2 expressions were ↓ in CRS-rats, as well as HO-1 and NQO-1mRNA, compared with the Ctrl group. Cilostazol (15 mg/kg/day) prevented ↓nuclear Nrf2, whereas cilostazol (30 mg/kg/day) prevented ↓ in cytoplasmic and nuclear Nrf2 expression. Cilostazol (15 mg/kg/day) prevented ↓ in HO-1, whereas cilostazol (30 mg/kg/day) prevented the decrease in both HO-1 and NQO-1 mRNA. The gene discussed is NQO1; the disease is congenital rubella syndrome.