Five groups of 8: (1) Ctrl; (2) stress Ctrl or positive Ctrl of depression: CORST (20 mg/kg) for 21 days; (3) fluoxetine (10 mg/kg) and CORST for 21 days; (4) Mito-TEMPO (1 mg/kg) and CORST; (5) fluoxetine, Mito-TEMPO and CORST. Behav tests (FST, TST). Evaluation of the level of mRNA expression of Adora1, Ogg1, Msra, Nrf2 and Tfam in mouse Hippoc. The gene discussed is NFE2L2; the disease is major depressive disorder.