Nrf2 deletion resulted in DLB (↑ in the immobility time in the TST and by a ↓ in the grooming time in the SPlT); ↓ of Dopa and Ser and ↑ Glu in the PFC;↑ of VEGF and synaptophysin;↑microgliosis. Nrf2 KO mice treatment with rofecoxib reversed their DLB; SFN in LPS-induced depression of WT mice afforded AD-like effects. This evidence concerns the gene SYP and Alzheimer disease.