IL-1β KO in the Hippoc ↓ the memory deficits, anxiety- and DLB induced by LPS in mice; it also ameliorated the oxidative and neuroinflammatory responses and abolished the ↓ of VGF and BDNF induced by LPS. Finally, the ↑MDA and ↓SOD, Nrf2 and HO1 induced by LPS were completely prevented with IL-1β shRNA. The gene discussed is BDNF; the disease is Lewy body dementia.