Single administration of ketamine (0.1 mg/kg, i.p.) + guanosine (0.01 mg/kg, p.o.) ↓ DLB and Hippoc slice impairments induced by CORT. The behav response obtained by Ketamine + Guanosine was paralleled by the re-establishment of the CORT-induced molecular alterations on Hippoc GR, NF-κB, IDO-1, and GLT-1 immunocontent. The gene discussed is NR3C1; the disease is Lewy body dementia.