Treatment with creatine↑ Akt and P70S6K phosphorylation, HO-1/Nrf2, GPx and PSD95 immunocontents. The pretreatment with LY294002 wortmannin, ZnPP (HO-1 inhibitor), or rapamycin (mTOR inhibitor) prevented the AD-like effect of creatine in the TST. Subbeffective dose of either the ARA014418, lithium chloride, or the HO-1 inductor CoPP + subeffective dose of creatine ↓ the immobility time in the TST. This evidence concerns the gene NFE2L2 and Alzheimer disease.