Fen ↑ antioxidant capacity in bEnd.3 cells after LPS exposure: ↑ SOD, ↑ GPx, ↑ CAT, ↓ ROS, ↓ MDA; ↓ apoptotic rate promoted by LPS; ↓ IL-1β, IL-18, IL-6, TNF-α, and NO; ↓ TNF-κB nuclear expression; ↓ phosphorylation of IKKβ, IκBα and NF-κB. Fen had minimal impact on mouse histological changes and could alleviate symptoms of LPS-induced DLB. The gene discussed is TNF; the disease is Lewy body dementia.