Acupuncture/fluoxetine ↑ sugar preference SPT and ↓ immobility time in Behav test. Acupuncture ↓ Bax2/caspase-3 and ↑ Bcl-2. Acupuncture improved DLB of CUMS rats. Acupuncture showed AD effects in ↓oxidative stress products regulating the Nrf2/HO-1 pathway. Here, HMOX1 is linked to Alzheimer disease.