Application of rTMS exhibited significant AD and anxiolytic-like effects associated with ↑ Nrf2 nuclear translocation and ↓ level of TNF-α, iNOS, IL-1β, and IL-6 in the Hippoc. Following Nrf2 silencing, AD and anxiolytic-like effects produced by rTMS were abolished. Moreover, the ↑ of Nrf2 nuclear translocation, and the ↓of TNF-α, iNOS, IL-1β, and IL-6 in Hippoc mediated by rTMS, were reversed by Nrf2 knockdown. This evidence concerns the gene IL6 and Alzheimer disease.