SUS exhibited DLB, memory deficits and social withdrawal. qRT-PCR and WB analysis showed ↓ Nrf2, HO-1, NQO1 and p-ERK in SUS and ↑ Keap1. IF showed ↓GFAP+ astrocytes in SUS. SI after CUMS perpetuated DLB, memory deficits and social withdrawal (overall worsening in behav tests and no BW ↑); ERK/Keap1/Nrf2 signalling was suppressed in CUMS-SI (↓ Nrf2, ERK, and ↑ Keap1 compared to CUMS-SS). Here, NFE2L2 is linked to Lewy body dementia.