PRMT1−/− mice ameliorated LPS-induced DLB and ↑BDNF and PSD-95 expression. PRMT1 deletion alleviates LPS-induced brain injury; down-regulating LPS-promoted expression levels of GFAP and IBA-1 compared with PRMT1+/+ mice. PRMT1 deficiency ↓IL-1β and TNF-α in Hippoc and PFC of LPS-challenged mice, ↓ pNF-κB, ↑ SOD and GSH-pX activities in Hippoc and ↑ Nrf-2. Here, DLG4 is linked to Lewy body dementia.