TNF and obesity due to melanocortin 4 receptor deficiency: This correlation has been attributed to the obesity-dependent endocrine function of obese adipose tissue, which is capable of producing pro-inflammatory cytokines, such as Interleukin 6 (IL-6), Interleukin 8 (IL-8), leptin, and tumor necrosis factor-alpha (TNFα), that stimulate the monocyte/macrophage recruitment to the tumor microenvironment (TME) [1].