It has been reported that TFs mediate the functions of lncRNAs in several essential biological processes, such as the lnc-ISIR/IRF3 axis in autoinflammation [56], the lnc-MAF/MAFB axis in epidermal differentiation [57], and the lnc-ANRASSF1/PRC2 axis in cancer cell proliferation [58]. The gene discussed is IRF3; the disease is cancer.