The typical symptoms related to O138 E. coli infections are mostly caused by bacterial verotoxins and F18 adhesive fimbriae, which can impair the vascular endothelium of the small intestine, subcutis and brain and eventually cause subcutaneous oedema and neurological symptoms, such as convulsion, rear-leg ataxia, extensor rigidity, lateral recumbency, tremors, paralysis, dyspnea, opisthotonos and sudden death [16]. This evidence concerns the gene MAMLD1 and escherichia coli infection.