Galanthamine, huperzine, and other natural derivatives occurring in plants are used for the treatment of AD dementia phase; besides, several plants, including the Galanthus genus where the galantamine comes from, produces a bunch of metabolites such as alkaloids, terpenes, polyphenols, and others that have been assessed for their natural AChE inhibitory potential, becoming potential candidates for the discovery of AD alternative treatments [1]. The gene discussed is ACHE; the disease is Alzheimer disease.