The enzyme acetylcholinesterase (AChE) terminates the effect of ACh at the synapse, regulating its concentration [3]; however, when there is abnormal cholinergic activity, AChE catalyzes in excess the hydrolysis or deactivation of ACh in the cholinergic terminals, causing a decrease/deficit of this neurotransmitter, leading to neurodegenerative diseases [4]. The gene discussed is ACHE; the disease is neurodegenerative disease.