MAPK8 and myocardial ischemia: Importantly, 6-G exerts pharmacological effects by regulating the mitogen-activated protein kinase (MAPK) signaling pathway [16] and inhibits apoptosis to attenuate myocardial ischemia/reperfusion injury by activating the phosphatidylinositol 3-kinase/Akt and high mobility group box 2-c-Jun N-terminal kinase 1/2/3 (JNK1/2/3)-nuclear factor kappa B pathways [17].