However, it is downregulated in women with endometriosis (e.g., IL-15, glycodelin, proline-rich protein, B61, and N-acetylglucosamine-6-O-sulfotransferase (GlcNAc6ST)), whereas the second cluster comprised genes that are conversely downregulated during the normal implantation window but upregulated in endometriosis (e.g., semaphorin E, neuronal olfactomedin-related endoplasmic reticulum localized protein mRNA, and Sam68-like phosphotyrosine protein ⍺). The gene discussed is SEMA3C; the disease is endometriosis.