MTOR and early-onset autosomal dominant Alzheimer disease: The top 20 significantly enriched pathways are shown in Figure 7A, including the mTOR signaling pathway, the Huntington disease pathway, retrograde endocannabinoid signaling, the pathways of neurodegeneration–multiple diseases, that of prion disease, amyotrophic lateral sclerosis, oxidative phosphorylation, Alzheimer’s disease, and so on.