TNF and cancer: The KEGG pathway analysis identified significantly enriched pathways associated with the DEGs, including Herpes simplex virus one infection, mmu05168 (8.39%); pathways in cancer, mmu05200 (4.54%); cytokine–cytokine receptor interaction mmu04060, (3.84%); HIF-1 signaling pathway, mmu04066 (3.54%); NF-kappa B signaling pathway, mmu04064 (2.12%); Toll-like receptor signaling pathway, mmu04620 (1.12%); and TNF signaling pathway, mmu04668 (3.25%) (Figure 6A).