Thus, to characterize the cell-intrinsic polarity change in Dmp1 cKD mice, we focused on Gαi3 and Par6b as representatives of the Gαi/mInsc/LGN and aPKC-Par6 complexes, respectively, and examined whether their asymmetric distributions were abnormal in HCs of Dmp1 cKD mice. Here, PARD6A is linked to chronic kidney disease.