PDIA4 and malignant colon neoplasm: Further bioinformatics analyses of the five top-ranked hub proteins revealed their significantly (p < 0.05; q < 0.05) increased expression at the mRNA level in tumors from colon cancer patients with BRAFV600E mutation in comparison with an unaltered group (Figure 4a, Figures S8A, S9A, S10A and S11A) with the exception of PDIA4, where statistical significance was not reached.