Protein–protein interaction (PPI) network analysis and in silico evaluation of selected protein features using the BRAFV600E-mutated colon adenocarcinoma dataset in the Cancer Genome Atlas (TCGA) database pointed to replication protein A1 (RPA1) and heat shock protein family A (Hsp70) member 5 (HSPA5/GRP78) regulating DNA replication and the unfolded protein response, respectively, as potentially interesting protein targets associated with vemurafenib resistance. This evidence concerns the gene HSPA5 and colon adenocarcinoma.