Since the expression pattern of RPA1 and HSPA5/GRP78 in tumor tissues from colon cancer patients was found in in silico analyses to be associated with BRAFV600E mutation status, the possibility to extrapolate our findings and their clinical implication to other solid tumors harboring BRAFV600E mutation, such as melanoma, should also be further explored. This evidence concerns the gene HSPA5 and colonic neoplasm.