Exploring the role of APOE in modulating immunometabolism [21] and investigating a combination of approaches in the APOE–MHC-I neuronal axis, as well as APOE-induced MHC-I overexpression, including mechanisms inhibiting APOE expression and MHC-I-induced tau pathology, could prove beneficial in AD research [20]. The gene discussed is APOE; the disease is Alzheimer disease.