Taken together, the results across all four categories show that the reported causes of molecular imbalance are alterations in BA synthesis, loss of PITRM1 and TREM2 function, disruption of OM cells, dysregulated cholesterol catabolism, DSB neuronal damage, NFkB and P65KD silencing, tau expression, and neuronal APOE expression. The gene discussed is TREM2; the disease is ocular melanoma.