Using scRNA-seq analysis, sex-specific progression of dementia was found to be associated with cholesterol and BA synthesis, and transcriptomic profiles of BA receptors such as peroxisome proliferator activated receptor alpha & gamma (PPARA & PPARG), retinoic acid receptor alpha (RARA), and retinoid x receptor alpha (RXRA) were differentially expressed in a sex-specific manner [19], which was consistent with previous results by Baloni et al. [26]. The gene discussed is PPARA; the disease is dementia.