PITRM1 and Alzheimer disease: Potential molecular investigations may evaluate the impact of altering BA signaling and synthesis, sex-specific role of LRP1 regulation, AD-specific changes in OM cells and the entorhinal cortex, regulatory mechanisms initiating tau gene transcription, microglial TREM2 activation, and PITRM1 mechanistic links between mitochondrial disorders and neurological proteinopathies.