1. Amyloid plaques without microglia (XO4-) show signatures of transcription linked with accelerated aging and increased intracellular postsynaptic material compared to those without (XO4+)2. Aging microglia undergo transcriptional trajectory faster in AD, but upon plaque phagocytosis re-route to HIF1α regulon, resulting in increased Aβ phagocytosis. The gene discussed is HIF1A; the disease is Alzheimer disease.