1. There may be a link between altered mitochondrial respiration and a reduction of ATP production in AD OM cells. 2. The OM and entorhinal cortex, which are vulnerable to early AD pathogenesis may exhibit disease specific changes.3. There might be tissue-specific changes in low density lipoprotein receptor 1 (LRP1) in AD. The gene discussed is LRP1; the disease is ocular melanoma.