Potential molecular investigations may evaluate the impact of altering BA signaling and synthesis, sex-specific role of LRP1 regulation, AD-specific changes in OM cells and the entorhinal cortex, regulatory mechanisms initiating tau gene transcription, microglial TREM2 activation, and PITRM1 mechanistic links between mitochondrial disorders and neurological proteinopathies. The gene discussed is TREM2; the disease is Alzheimer disease.