Recent studies have pointed to CXCL10 and CCL2 involvement in microglial activation and AD pathogenesis [11], and the merits of this requires investigation because neurons with DSBs are centers for neuroimmune communication and imbalance in CCL2 and CXCL10 axis may have damaging effects on cognition [11]. The gene discussed is CXCL10; the disease is Alzheimer disease.