Although five major variants in genes associated exclusively with NAFLD, such as patatin-like phospholipase domain-containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), glucokinase regulator (GCKR), membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), and hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13), have been described, rare variants were also reported in NAFLD patients [14]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.