However, in both genetic hepatic-specific PGC-1β-overexpressing (LivPGC-1β) and diethylnitrosamine (DEN)-induced HCC mouse models, PGC-1β plays an important role in HCC development, sustaining metabolic reprogramming through the induction of lipogenic enzymes and promoting tumor growth [128]. The gene discussed is PPARGC1B; the disease is neoplasm.