The MBOAT7 variant (rs641738 C>T MBOAT7/TMC4) reduces the levels of the MBOAT7 protein in the liver and predisposes to advance forms of NAFLD, mainly by modifying the hepatic levels of phosphatidylinositol (PI) and LPI and stimulating hyperinsulinemia and hepatic IR [23,24]. This evidence concerns the gene MBOAT7 and Hyperinsulinemia.