PINK1 and cardiac hypertrophy: Eight weeks after surgery, pathological cardiac hypertrophy in the TAC mice was mitigated by PINK1 overexpression (Figure 2A). Compared to the sham mice, the HW:BW ratio and HW:TL ratio in the TAC mice increased by 68.47% and 73.57%, respectively (Figure S3 in the Supplementary Materials).