AIFM3 and neoplasm: AIFM3, which is expressed almost exclusively in the brain, was expressed at a higher level in tumors where the TCR CDR3-CTA CSs were low, which is consistent with the idea that a high TCR CDR3-CTA CS is not representative of tumor cell killing by T-cells, i.e., lower DFS probabilities were consistent with the highly likely lack of apoptosis in the tumor samples.