Alzheimer’s disease is characterized by two pathological features, involving deposits of misfolded proteins, i.e., extracellular deposition of amyloid-β (Aβ), leading to amyloid plaques and intracellular accumulation of hyperphosphorylated Tau in neurofibrillary tangles (NFTs) [376]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.