In particular, IL-1β, TNF-α, and IL-6 are secreted upon exposure to LPS from the P.gingivalis, which plays a pivotal role in bone resorption, peri-implantitis, and periodontitis apart from the role of these cytokines in other systemic inflammatory conditions, thus making these cytokines prime targets for therapeutic strategies [14,15,16,17], Along these lines, this scoping review aims to highlight if simultaneous increases in the serums IL-1β, IL-6, and TNF-α in periodontitis and COVID-19 infection patients could indicate an association between periodontitis and the coronavirus infection. The gene discussed is IL6; the disease is periodontitis.