It is important to note that some polymorphism may have trivial effects on LHCGR activity and, considering that a large portion of the LHCGR gene, including exon 10, is fixed into the intronic region of the TFIIAalpha/beta-like factor (ALF) gene that is also associated to male infertility [86], it is possible that the related pathological manifestations are due to the physiological activity of ALF gene. This evidence concerns the gene LHCGR and male infertility.