PLOD1 and amenorrhea: Two types of LCH have been defined: LCH type I is the severe form caused by the total inactivation of LHCGR, and it is characterized by complete 46, XY male pseudohermaphroditism with female external genitalia, underdeveloped and retained testes, lack of breast development, amenorrhea, unresponsiveness to LH/hCG, low testosterone and high LH levels in serum, and a lack of secondary male sex characteristics; LCH type II is a milder form in which mutated LHCGR retains some functionality, and it is phenotypically associated with a micropenis, cryptorchidism, and hypospadias.