The clinical application of blocking PD-1 with anti-PD-1 antibodies displays successful outcomes, and it is reported that blockade of PD-1 or PD-L1 improves the cytolytic activity of exhausted CD8+T cells, enhances inflammatory cytokines production, and reduces the viral load and tumor burden in a mouse model [14,31,43]; this implies that the exhausted T cell state is not irreversible. This evidence concerns the gene CD8A and neoplasm.