The atrophy-related genes Muscle Atrophy F-box (MAFbx), Muscle Ring-Finger Protein-1 (Mu-RF1), Ubiquitin C (Ubc), Forkhead box protein O1 (Foxo1), Forkhead box protein O3a (Foxo3a), Regulated in Development and DNA damage responses 1 (Redd1) and Krüppel-like factor 15 (Klf15) were higher in the SPF group than the SF group and not different between the SPF and Sepsis mice. The gene discussed is FOXO3; the disease is Sepsis.