Interestingly, the endogenous steroids 3α,5α-tetrahydrocorticosterone and 3α,5β-tetrahydrocorticosterone (5α- and 5β-THB) were recently identified as physiologically relevant AhR ligands with roles in promoting neuronal development and differentiation, and these compounds were also found to induce the differentiation of neuroblastoma cells [129]. The gene discussed is AHR; the disease is neuroblastoma.