−251 (C > G) variation alone was also found in association with the S102P polymorphism in a 28-year-old woman with moderate anemia who was heterozygous for the β039 mutation (Table 3, subject 4) and in association with the F182L mutation in a 30-year-old man negative for thalassemia mutations with borderline HbA2 levels (3.2%) (Table 3, patient 11). Here, HBA2 is linked to anemia (phenotype).