MTM1 and centronuclear myopathy: Nesrin et al. [37] showed that PIK3C2B (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta) could trigger specific muscle ablation and is identified as a genetic modifier of MTM1 mutation, and here we know that mutation of MTM1 is the cause of myotubular myopathy.