MICAL2 and pulmonary arterial hypertension: The first study examined its role in pulmonary VSMC (pVSMC) proliferation and demonstrated that restoration of miR-205-5p, which was downregulated during hypoxia-induced pulmonary arterial hypertension (PAH), inhibited pVSMC proliferation by targeting molecules interacting with CasL 2 (MICAL2) [144], a cytoskeleton dynamics regulator known to promote cancer cell proliferation [145].