CALR and neoplasm: This adaptive immunity against tumor cells is associated with the immunogenic cell death (ICD) induced by ALA-PDT, which the expression of damage-associated molecular patterns (DAMPs) molecules such as calreticulin, heat shock proteins-70, and high mobility group box 1 (HMGB1) in PDT-treated tumor cells stimulates dendritic cell maturation and promotes tumor cell antigen presentation to T lymphocytes [152,153].