In addition to the evidence provided in our results (Fig. 2 and Fig. 3c, Supplementary Figs. 9 and 10), the FBLN1 gene has been associated with a rare genetic syndrome that includes multiple cognitive impairments, and protein levels of FBLN1 have been associated with altered risk for ischaemic stroke (Palumbo et al. Here, FBLN1 is linked to ischemic stroke.