After applying a combination of high glucose plus palmitate to mimic the effects of the microenvironment of T2DM on osteoclast differentiation, Qu et al. found that this environment promoted differentiation of osteoclast precursors into osteoclasts by decreasing OPG expression and increasing levels of RANK, RANKL, and NFATc1. Here, TNFSF11 is linked to type 2 diabetes mellitus.