SOST and type 2 diabetes mellitus: However, in an analysis of 40 postmenopausal women with type 2 diabetes mellitus (T2DM) and 40 healthy controls, Gaudio et al. found that β-catenin levels were significantly lower in women with T2DM compared with those in the control group, which may be related to the production of AGEs and increase of SOST [65].